Comparison of two ASC-derived therapeutics in an in vitro OA model: secretome versus extracellular vesicles

Abstract Background In the last years, several clinical trials have proved the safety and efficacy of adipose-derived stem/stromal cells (ASC) in contrasting osteoarthritis (OA). Since ASC act mainly through paracrine mechanisms, their secretome (conditioned medium, CM) represents a promising therap...

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Bibliographic Details
Main Authors: Chiara Giannasi, Stefania Niada, Cinzia Magagnotti, Enrico Ragni, Annapaola Andolfo, Anna Teresa Brini
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Stem Cell Research & Therapy
Subjects:
Online Access:https://doi.org/10.1186/s13287-020-02035-5