Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis

Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis

Abstract Background Thrombospondin-related adhesive protein (TRAP) is a transmembrane protein that plays a crucial role during the invasion of Plasmodium falciparum into liver cells. As a potential malaria vaccine candidate, the genetic diversity and natural selection of PfTRAP was assessed and the...

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Bibliographic Details
Main Authors: Li-Yun Lin, Hui-Ying Huang, Xue-Yan Liang, Dong-De Xie, Jiang-Tao Chen, Hua-Gui Wei, Wei-Yi Huang, Carlos Salas Ehapo, Urbano Monsuy Eyi, Jian Li, Jun-Li Wang, Yu-Zhong Zheng, Guang-Cai Zha, Yu-Ling Wang, Wei-Zhong Chen, Xiang-Zhi Liu, Huan-Tong Mo, Xin-Yao Chen, Min Lin
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum thrombospondin-related adhesive protein (PfTRAP)
Genetic diversity
Natural selection
Bioko Island
Malaria
Vaccine candidate
Online Access:https://doi.org/10.1186/s12936-021-03664-8

Internet

https://doi.org/10.1186/s12936-021-03664-8

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