<i>Rickettsia parkeri</i> with a Genetically Disrupted Phage Integrase Gene Exhibits Attenuated Virulence and Induces Protective Immunity against Fatal Rickettsioses in Mice

<i>Rickettsia parkeri</i> with a Genetically Disrupted Phage Integrase Gene Exhibits Attenuated Virulence and Induces Protective Immunity against Fatal Rickettsioses in Mice

Although rickettsiae can cause life-threatening infections in humans worldwide, no licensed vaccine is currently available. To evaluate the suitability of live-attenuated vaccine candidates against rickettsioses, we generated a <i>Rickettsia parkeri</i> mutant RPATATE_0245::pLoxHimar (na...

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Bibliographic Details
Main Authors: Esteban Arroyave, Ilirjana Hyseni, Nicole Burkhardt, Yong-Fang Kuo, Tian Wang, Ulrike Munderloh, Rong Fang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pathogens
Subjects:
rickettsial mutant
attenuated virulence
protective immunity
fatal murine rickettsioses
Online Access:https://www.mdpi.com/2076-0817/10/7/819

Internet

https://www.mdpi.com/2076-0817/10/7/819

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