Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors

A series of novel isatin-thiazole derivatives were synthesized and screened for their in vitro α-glucosidase inhibitory activity. These compounds displayed a varying degree of α-glucosidase inhibitory activity with IC50 ranging from 5.36 ± 0.13 to 35.76 ± 0.31 μm as compared to the standard drug aca...

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Bibliographic Details
Main Authors: Zhenzhen Xie, Guangcheng Wang, Jing Wang, Ming Chen, Yaping Peng, Luyao Li, Bing Deng, Shan Chen, Wenbiao Li
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Molecules
Subjects:
α-glucosidase inhibitor
molecular docking
isatin
thiazole
diabetic
Online Access:http://www.mdpi.com/1420-3049/22/4/659

Internet

http://www.mdpi.com/1420-3049/22/4/659

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