Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice

Abstract Background Recently, clinical studies have shown the protective effects of sodium glucose co-transporter2 (SGLT2) inhibitors against progression of diabetic nephropathy, but the underlying molecular mechanisms remain unclear. Methods Diabetic mice were prepared by injecting nicotinamide and...

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Bibliographic Details
Main Authors: Masa-Ki Inoue, Yasuka Matsunaga, Yusuke Nakatsu, Takeshi Yamamotoya, Koji Ueda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Misaki Iwashita, Tomomi Sano, Fusanori Nishimura, Kenichi Morii, Kensuke Sasaki, Takao Masaki, Tomoichiro Asano
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Diabetes mellitus
Nephropathy
SGLT2 inhibitor
Canagliflozin
AMPK
Pin1
Online Access:http://link.springer.com/article/10.1186/s13098-019-0454-6

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http://link.springer.com/article/10.1186/s13098-019-0454-6

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