PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

Inactivation of the Pancreatic and Duodenal Homeobox 1 (PDX1) gene causes pancreatic agenesis, which places PDX1 high atop the regulatory network controlling development of this indispensable organ. However, little is known about the identity of PDX1 transcriptional targets. We simulated pancreatic...

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Bibliographic Details
Main Authors: Adrian Kee Keong Teo, Norihiro Tsuneyoshi, Shawn Hoon, Ee Kim Tan, Lawrence W. Stanton, Christopher V.E. Wright, N. Ray Dunn
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000715

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http://www.sciencedirect.com/science/article/pii/S2213671115000715

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