Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability

Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability

Radiotherapy efficacy is the result of radiation-mediated cytotoxicity coupled with stimulation of antitumor immune responses. We develop an in silico 3-dimensional agent-based model of diverse tumor-immune ecosystems (TIES) represented as anti- or pro-tumor immune phenotypes. We validate the model...

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Bibliographic Details
Main Authors: Juan C.L. Alfonso, G. Daniel Grass, Eric Welsh, Kamran A. Ahmed, Jamie K. Teer, Shari Pilon-Thomas, Louis B. Harrison, John L. Cleveland, James J. Mulé, Steven A. Eschrich, Javier F. Torres-Roca, Heiko Enderling
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Radiosensitivity
Immune infiltrate
Agent-based model
Mathematical model
Personalized medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000786

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http://www.sciencedirect.com/science/article/pii/S1476558621000786

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