Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Drugs that recapitulate aspects of the exercise adaptive response have the potential to provide better treatment for diseases associated with physical inactivity. We previously observed reduced skeletal muscle class IIa HDAC (histone deacetylase) transcriptional repressive activity during exercise....

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Bibliographic Details
Main Authors: Vidhi Gaur, Timothy Connor, Andrew Sanigorski, Sheree D. Martin, Clinton R. Bruce, Darren C. Henstridge, Simon T. Bond, Kevin A. McEwen, Lyndal Kerr-Bayles, Trent D. Ashton, Cassandra Fleming, Min Wu, Lisa S. Pike Winer, Denise Chen, Gregg M. Hudson, John W.R. Schwabe, Keith Baar, Mark A. Febbraio, Paul Gregorevic, Frederick M. Pfeffer, Ken R. Walder, Mark Hargreaves, Sean L. McGee
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
Skeletal muscle
HDAC4
HDAC5
MEF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310518

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http://www.sciencedirect.com/science/article/pii/S2211124716310518

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