Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis

Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis

We previously showed that treatment with lanthionine ketimine ethyl ester (LKE) reduced disease severity and axonal damage in an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis and increased neuronal maturation and survival in vitro . A major target of LKE is collap...

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Bibliographic Details
Main Authors: Aubin Moutal, Sergey Kalinin, Kathy Kowal, Natalia Marangoni, Jeffrey Dupree, Shao Xia Lin, Kinga Lis, Lucia Lisi, Kenneth Hensley, Rajesh Khanna, Douglas L. Feinstein
Format: Article
Language:English
Published: SAGE Publishing 2019-12-01
Series:ASN Neuro
Online Access:https://doi.org/10.1177/1759091419892090

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https://doi.org/10.1177/1759091419892090

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