Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia

Metabotropic glutamate (mGlu) receptors are considered as candidate drug targets for the treatment of schizophrenia. These receptors form a family of eight subtypes (mGlu1 to −8), of which mGlu1 and −5 are coupled to Gq/11, and all other subtypes are coupled to Gi/o. Here, we discuss the possibility...

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Bibliographic Details
Main Authors: Ferdinando Nicoletti, Rosamaria Orlando, Luisa Di Menna, Milena Cannella, Serena Notartomaso, Giada Mascio, Luisa Iacovelli, Francesco Matrisciano, Francesco Fazio, Filippo Caraci, Agata Copani, Giuseppe Battaglia, Valeria Bruno
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Psychiatry
Subjects:
metabotropic glutamate receptors
schizophrenia
positive allosteric modulator
development of cortical interneurons
receptor cross-talk
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00049/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00049/full

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