Loss of Stromal Galectin-1 Enhances Multiple Myeloma Development: Emphasis on a Role in Osteoclasts

Loss of Stromal Galectin-1 Enhances Multiple Myeloma Development: Emphasis on a Role in Osteoclasts

Multiple myeloma osteolytic disease is caused by an uncoupled bone-remodelling process with an increased osteoclast activity. Disease development relies on interactions between myeloma cells and bone marrow stromal cells. Recent findings suggest a role for glycan-binding proteins in myeloma microenv...

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Bibliographic Details
Main Authors: Joséphine Muller, Elodie Duray, Margaux Lejeune, Sophie Dubois, Erwan Plougonven, Angélique Léonard, Paola Storti, Nicola Giuliani, Martine Cohen-Solal, Ute Hempel, Victor L. Thijssen, Yves Beguin, Roy Heusschen, Jo Caers
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
multiple myeloma
osteolytic disease
galectin-1
osteoclasts
tumour microenvironment
Online Access:https://www.mdpi.com/2072-6694/11/2/261

Internet

https://www.mdpi.com/2072-6694/11/2/261

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