The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse.

The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse.

Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. Recently, a HER2 splice variant lacking exon-16 (Δ16HER2) has been detected in human breast carcinomas. This alternative protein, a normal byproduct of HER2, has an incr...

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Bibliographic Details
Main Authors: Cristina Marchini, Federico Gabrielli, Manuela Iezzi, Santa Zenobi, Maura Montani, Lucia Pietrella, Cristina Kalogris, Anna Rossini, Valentina Ciravolo, Lorenzo Castagnoli, Elda Tagliabue, Serenella M Pupa, Piero Musiani, Paolo Monaci, Sylvie Menard, Augusto Amici
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084693?pdf=render

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http://europepmc.org/articles/PMC3084693?pdf=render

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