A Critical Role for the TLR4/TRIF Pathway in Allogeneic Hematopoietic Cell Rejection by Innate Immune Cells

A Critical Role for the TLR4/TRIF Pathway in Allogeneic Hematopoietic Cell Rejection by Innate Immune Cells

We show for the first time that signaling through the TLR4/TRIF pathway plays a critical role in allogeneic bone marrow cell (BMC) rejection. This appears to be unique to BMCs as organ allografts are rejected mainly via MyD88 signaling. Using T- or T-/B-cell-deficient mice, we found that BMC allorej...

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Bibliographic Details
Main Authors: Hong Xu, Jun Yan, Ziqiang Zhu, Lala-Rukh Hussain, Yiming Huang, Chuanlin Ding, Larry D. Bozulic, Yujie Wen, Suzanne T. Ildstad M.D.
Format: Article
Language:English
Published: SAGE Publishing 2013-12-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X658881

Internet

https://doi.org/10.3727/096368912X658881

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