Effect of β-Eudesmol on NQO1 suppression-enhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents

Effect of β-Eudesmol on NQO1 suppression-enhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents

Abstract Background Cholangiocarcinoma (CCA), an epithelial malignancy of the biliary tree, is one of the aggressive cancers with poor prognosis and unsatisfactory response to chemotherapy with acquired resistance. NAD(P)H-quinone oxidoreductase 1 (NQO1), an antioxidant/detoxifying enzyme, plays imp...

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Bibliographic Details
Main Authors: Pimradasiri Srijiwangsa, Saranyoo Ponnikorn, Kesara Na-Bangchang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Pharmacology and Toxicology
Subjects:
Cholangiocarcinoma
NAD(P)H-quinone oxidoreductase 1
β-Eudesmol
5-Fluorouracil
Doxorubicin
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s40360-018-0223-4

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http://link.springer.com/article/10.1186/s40360-018-0223-4

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