Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37

Parkinson’s disease (PD) etiology is attributed to aging and the progressive neurodegeneration of dopamine (DA) neurons of substantia nigra pars compacta (SNc). GPR37 is an orphan G-protein Coupled Receptor (GPCR) that is linked to the juvenile form of PD. In addition, misfolded GPR37 has been found...

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Bibliographic Details
Main Authors: Xiaoqun Zhang, Ioannis Mantas, Elva Fridjonsdottir, Per E. Andrén, Karima Chergui, Per Svenningsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
6-hydroxydopamine
striatum
synaptic plasticity
GPR37
PAEL-R
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00084/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00084/full

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