Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities

Evolutionary dynamics can be used to control cancers when a cure is not clinically considered to be achievable. Understanding Darwinian intratumoral interactions of microenvironmental selection forces can be used to steer tumor progression towards a less invasive trajectory. Here, we approach intrat...

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Bibliographic Details
Main Authors: Bryce Ordway, Michal Tomaszewski, Samantha Byrne, Dominique Abrahams, Pawel Swietach, Robert J. Gillies, Mehdi Damaghi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
evolutionary therapy
darwinian evolution
tumor microenvironment
cancer cells subpopulations
diclofenac
koningic acid
Online Access:https://www.mdpi.com/2072-6694/13/1/64

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https://www.mdpi.com/2072-6694/13/1/64

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