Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability

Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability

Abstract Background The accumulation of mtDNA mutations in different tissues from various mouse models has been widely studied especially in the context of mtDNA mutation-driven ageing but has been confounded by the inherent limitations of the most widely used approaches. By implementing a method to...

Full description

Bibliographic Details
Main Authors: Emilie Kristine Bagge, Noriko Fujimori-Tonou, Mie Kubota-Sakashita, Takaoki Kasahara, Tadafumi Kato
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Biology
Subjects:
Mitochondrial DNA
Polymerase gamma
Polg
Ageing
Mitochondrion
mtDNA mutation
Online Access:http://link.springer.com/article/10.1186/s12915-020-00890-5

Internet

http://link.springer.com/article/10.1186/s12915-020-00890-5

Similar Items