The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs

The human RNA exosome contains a nuclear co-factor MTR4, which unwinds structural RNAs and recruits adaptors for different RNA processing and decay pathways. Here the authors uncover new variations of the arch-interacting motif (AIM) in NVL and ZCCHC8 and characterise their interaction with MTR4.

Bibliographic Details
Main Authors: Mahesh Lingaraju, Dennis Johnsen, Andreas Schlundt, Lukas M. Langer, Jérôme Basquin, Michael Sattler, Torben Heick Jensen, Sebastian Falk, Elena Conti
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11339-x

Internet

https://doi.org/10.1038/s41467-019-11339-x

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