The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer...

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Bibliographic Details
Main Authors: Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journé, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03609-x

Internet

https://doi.org/10.1038/s41467-018-03609-x

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