A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms

A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms

Summary: Human antibody SIgN-3C neutralizes dengue virus (DENV) and Zika virus (ZIKV) differently. DENV:SIgN-3C Fab and ZIKV:SIgN-3C Fab cryoelectron microscopy (cryo-EM) complex structures show Fabs crosslink E protein dimers at extracellular pH 8.0 condition and also when further incubated at acid...

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Bibliographic Details
Main Authors: Shuijun Zhang, Thomas Loy, Thiam-Seng Ng, Xin-Ni Lim, Shyn-Yun Valerie Chew, Ter Yong Tan, Meihui Xu, Victor A. Kostyuchenko, Farhana Tukijan, Jian Shi, Katja Fink, Shee-Mei Lok
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305337

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http://www.sciencedirect.com/science/article/pii/S2211124720305337

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