Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia

Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia

Abstract Background Several genetic alterations have been identified as driver events in chronic lymphocytic leukemia (CLL) pathogenesis and oncogenic evolution. Concurrent driver alterations usually coexist within the same tumoral clone, but how the cooperation of multiple genomic abnormalities con...

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Bibliographic Details
Main Authors: Miguel Quijada‐Álamo, Claudia Pérez‐Carretero, María Hernández‐Sánchez, Ana‐Eugenia Rodríguez‐Vicente, Ana‐Belén Herrero, Jesús‐María Hernández‐Sánchez, Marta Martín‐Izquierdo, Sandra Santos‐Mínguez, Mónica del Rey, Teresa González, Araceli Rubio‐Martínez, Alfonso García de Coca, Julio Dávila‐Valls, José‐Ángel Hernández‐Rivas, Helen Parker, Jonathan C. Strefford, Rocío Benito, José‐Luis Ordóñez, Jesús‐María Hernández‐Rivas
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical and Translational Medicine
Subjects:
biomarkers
chromosomal abnormality
chronic lymphocytic leukemia
CRISPR/Cas9 system
next‐generation sequencing
TP53 gene
Online Access:https://doi.org/10.1002/ctm2.304

Internet

https://doi.org/10.1002/ctm2.304

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