Low frequency of mismatch repair deficiency in gallbladder cancer

Low frequency of mismatch repair deficiency in gallbladder cancer

Abstract Background DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as microsatellite instability (MSI). MSI tumors have a distinct clinical behav...

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Bibliographic Details
Main Authors: Benjamin Goeppert, Stephanie Roessler, Marcus Renner, Moritz Loeffler, Stephan Singer, Melina Rausch, Thomas Albrecht, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Elena Czink, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Peter Schirmacher, Magnus von Knebel Doeberitz, Matthias Kloor
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Diagnostic Pathology
Subjects:
Biliary tract cancer
Gallbladder cancer
DNA mismatch repair deficiency
Microsatellite instability
Online Access:http://link.springer.com/article/10.1186/s13000-019-0813-5

Internet

http://link.springer.com/article/10.1186/s13000-019-0813-5

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