Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.

Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.

<h4>Background</h4>Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellul...

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Bibliographic Details
Main Authors: Nicolas Mercado, Yasuo Kizawa, Keitaro Ueda, Yeping Xiong, Genki Kimura, Audric Moses, Jonathan M Curtis, Kazuhiro Ito, Peter J Barnes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505412/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505412/?tool=EBI

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