Insulin receptor has tyrosine kinase activity toward Shc in rat liver

Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated. In the present study, we investigated insulin-induced IR tyros...

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Bibliographic Details
Main Authors: E.V. Páez-Espinosa, C.R.O. Carvalho, L.A. Velloso, M.J.A. Saad
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 1998-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Shc
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001100008