IDH1 as a frequently mutated gene has potential effect on exosomes releasement by epigenetically regulating P2RX7 in intrahepatic cholangiocarcinoma

IDH1 as a frequently mutated gene has potential effect on exosomes releasement by epigenetically regulating P2RX7 in intrahepatic cholangiocarcinoma

Biliary tract cancers (BTCs) was heterogeneous and characterized by late diagnosis and fatal outcome. To identify new biomarkers for BTCs, we performed Robust Rank Aggreg (RRA) analysis and identified that IDH1 mutation was common in ICC, while IDH1R132C was the most frequent type. Moreover, we iden...

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Bibliographic Details
Main Authors: Xing Zhang, Runchen Miao, Tian Liu, Xiaohong Xiang, Jingxian Gu, Yifan Jia, Zeyu Li, Yunong Fu, Yang He, Yuhua Zhang, Jingyao Zhang, Kai Qu, Chang Liu
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Intrahepatic cholangiocarcinoma
Gene mutation
IDH1
P2RX7
Exosomes
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219300897

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http://www.sciencedirect.com/science/article/pii/S0753332219300897

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