Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration

Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration

Multiple viral targets are now available in the clinic to fight HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic failures in patients due to resistance, with or without treatment-adherence glitches. According...

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Bibliographic Details
Main Authors: Chloé Torres, Asja Garling, Saïd Taouji, Christina Calmels, Marie-Line Andreola, Mathieu Métifiot
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
high-throughput screening
protein–protein interaction
integrated stress response
HIV integration
AlphaLISA
drug repurposing
Online Access:https://www.mdpi.com/1420-3049/26/17/5423

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https://www.mdpi.com/1420-3049/26/17/5423

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