Long-term chemical castration induces depressive symptoms by suppressing serotonin expression in rats

Androgen deprivation therapy, also known as chemical castration, has been used as an adjunct to psychotherapy for sex offenders. Goserelin and bicalutamide are drugs used for chemical castration. Serotonin (5-hydroxytryptamine, 5-HT) is a key neurotransmitter involved in mood changes, such as depres...

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Bibliographic Details
Main Authors: Jin-Hee Han, Mal-Soon Shin, Jae-Min Lee, Tae-Woon Kim, Jun-Jang Jin, Il-Gyu Ko, Sung-Eun Kim, Chang-Ju Kim, Mia Kim, Joo Hwan Roh, Khae Hawn Kim
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Animal Cells and Systems
Subjects:
Online Access:http://dx.doi.org/10.1080/19768354.2018.1427626