Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the thera...

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Bibliographic Details
Main Authors: Sabrina Reinehr, Sara C. Gomes, Caroline J. Gassel, M. Ali Asaad, Gesa Stute, Marc Schargus, H. Burkhard Dick, Stephanie C. Joachim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
glaucoma
complement
complement inhibition
membrane attack complex
optical coherence tomography
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01381/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01381/full

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