MiR-130a alleviated high-glucose induced retinal pigment epithelium (RPE) death by modulating TNF-α/SOD1/ROS cascade mediated pyroptosis

MiR-130a alleviated high-glucose induced retinal pigment epithelium (RPE) death by modulating TNF-α/SOD1/ROS cascade mediated pyroptosis

High-glucose induced retinal pigment epithelium (RPE) death by triggering oxidative stress, however, the underlying mechanisms are still not fully delineated. In this study, the RPE cell line ARPE-19 were treated with different concentrations of glucose, the results showed that high-glucose (50 mM)...

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Bibliographic Details
Main Authors: Xiaoting Xi, Yanni Yang, Jia Ma, Qianbo Chen, Yong Zeng, Junxian Li, Lin Chen, Yan Li
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
miR-130a
Retinal pigment epithelium
SOD1
ROS
Pyroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220301141

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http://www.sciencedirect.com/science/article/pii/S0753332220301141

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