Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer.

Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer.

Differentially methylated regions (DMRs) are associated with many imprinted genes. In mice methylation at a DMR upstream of the H19 gene known as the Imprint Control region (IC1) is acquired in the male germline and influences the methylation status of DMRs 100 kb away in the adjacent Insulin-like g...

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Bibliographic Details
Main Authors: Adele Murrell, Yoko Ito, Gaetano Verde, Joanna Huddleston, Kathryn Woodfine, Margherita Cirillo Silengo, Filippo Spreafico, Daniela Perotti, Agostina De Crescenzo, Angela Sparago, Flavia Cerrato, Andrea Riccio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2268001?pdf=render

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http://europepmc.org/articles/PMC2268001?pdf=render

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