<i>In Silico</i> Finding of Key Interaction Mediated α3β4 and α7 Nicotinic Acetylcholine Receptor Ligand Selectivity of Quinuclidine-Triazole Chemotype

<i>In Silico</i> Finding of Key Interaction Mediated α3β4 and α7 Nicotinic Acetylcholine Receptor Ligand Selectivity of Quinuclidine-Triazole Chemotype

The selective binding of six (<i>S</i>)-quinuclidine-triazoles and their (<i>R</i>)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by <i>in silico</i> docking to provide the insight into the molecular basi...

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Bibliographic Details
Main Authors: Kuntarat Arunrungvichian, Sumet Chongruchiroj, Jiradanai Sarasamkan, Gerrit Schüürmann, Peter Brust, Opa Vajragupta
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
stereoselectivity
anti-1,2,3-triazole
α7 nAChR
α3β4 nAChR
quinuclidine
Online Access:https://www.mdpi.com/1422-0067/21/17/6189

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https://www.mdpi.com/1422-0067/21/17/6189

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