Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy

Abstract Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor. There is a pressing need to further characterize factors in the microenvironment of BM that may confer resistance to r...

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Bibliographic Details
Main Authors: Aurélien Corroyer-Dulmont, Samuel Valable, Jade Fantin, Laurent Chatre, Jérôme Toutain, Sylvain Teulier, Céline Bazille, Elise Letissier, Jérôme Levallet, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Cécile Perrio, Louisa Barré, Sébastien Serres, Nicola R. Sibson, Françoise Chapon, Guénaëlle Levallet, Myriam Bernaudin
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90662-0