Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats

Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats

Abstract Background Aging has detrimental effects on the ovary, such as a progressive reduction in fertility and decreased hormone production, that greatly reduce the quality of life of women. Thus, the current study was undertaken to investigate whether human placenta-derived mesenchymal stem cell...

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Bibliographic Details
Main Authors: Kyeoung-Hwa Kim, Eun-Young Kim, Gi Jin Kim, Jung-Jae Ko, Kwang Yul Cha, Mi Kyung Koong, Kyung-Ah Lee
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Stem Cell Research & Therapy
Subjects:
Aging
Stem cell therapy
Hormone biosynthesis
miR-145
Primordial follicle activation
Follicular development
Online Access:http://link.springer.com/article/10.1186/s13287-020-01988-x

Internet

http://link.springer.com/article/10.1186/s13287-020-01988-x

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