Editorial focus: understanding off-target effects as the key to successful RNAi therapy

Editorial focus: understanding off-target effects as the key to successful RNAi therapy

Abstract With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we witness the RNAi therapy field reaching a critical turning point, when further improvements in drug candidate design and delivery pipelines should enable fast delivery of novel life changing treatments to p...

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Bibliographic Details
Main Authors: Rafal Bartoszewski, Aleksander F. Sikorski
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
ncRNAs
microRNAs
siRNAs
RNAi therapy
RNAi drug candidates
Off-target effects
Online Access:https://doi.org/10.1186/s11658-019-0196-3

Internet

https://doi.org/10.1186/s11658-019-0196-3

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