Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems
Abstract Background Hypertension may result from high-fat (HF) diet induced-obesity and overexposure to glucocorticoids in utero. Recent studies demonstrated the potent contribution of adipose tissue’s renin-angiotensin system (RAS) to systemic RAS, which plays a key role in regulating blood pressur...
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doaj-ee51eea2365147c39e4b6c0429f41f2c2020-11-25T00:55:10ZengBMCLipids in Health and Disease1476-511X2018-03-0117111010.1186/s12944-018-0701-0Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systemsHong-Ren Yu0You-Lin Tain1Mao-Meng Tiao2Chih-Cheng Chen3Jiunn-Ming Sheen4I-Chun Lin5Shih-Wen Li6Ching-Chou Tsai7Yu-Ju Lin8Kai-Sheng Hsieh9Li-Tung Huang10Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterDepartment of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical CenterAbstract Background Hypertension may result from high-fat (HF) diet induced-obesity and overexposure to glucocorticoids in utero. Recent studies demonstrated the potent contribution of adipose tissue’s renin-angiotensin system (RAS) to systemic RAS, which plays a key role in regulating blood pressure (BP). In this study, we investigated the effects of prenatal dexamethasone (DEX) exposure and postnatal HF diet on RAS of adipose tissue. Methods RAS and BP of 6-month old rats exposed to prenatal DEX and/or postnatal HF diet were examined. Results Prenatal DEX plus postnatal HF exerted a synergistic effect on systolic BP. Prenatal DEX exposure suppressed plasma angiotensin (ANG) I and ANG II, whereas postnatal HF suppressed plasma ANG-(1–7) level. Prenatal DEX increased prorenin receptor and renin levels, but suppressed angiotensinogen (AGT) and angiotensin-converting-enzyme 1 (ACE1) mRNA expressions in adipose tissue. Postnatal HF increased AGT mRNA expression, but suppressed prorenin receptor, renin, ACE2, ANG II type 2 receptor (AT2R), and Mas receptor (MasR) mRNA expression levels. Conclusions Prenatal GC exposure altered the ACE1/ANG II/ANG II type 1 receptor (AT1R) axis, whereas postnatal HF negatively impacted the ACE2/ANG-(1–7)/MasR axis. Prenatal DEX exposure and postnatal HF synergistically elevated BP through a distinct programming mechanism of systemic and adipose RAS. Adipose RAS might be a target for precise hypertension treatment.http://link.springer.com/article/10.1186/s12944-018-0701-0Prenatal glucocorticoidHigh-fat dietAdipose tissueRenin–angiotensin system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong-Ren Yu You-Lin Tain Mao-Meng Tiao Chih-Cheng Chen Jiunn-Ming Sheen I-Chun Lin Shih-Wen Li Ching-Chou Tsai Yu-Ju Lin Kai-Sheng Hsieh Li-Tung Huang |
spellingShingle |
Hong-Ren Yu You-Lin Tain Mao-Meng Tiao Chih-Cheng Chen Jiunn-Ming Sheen I-Chun Lin Shih-Wen Li Ching-Chou Tsai Yu-Ju Lin Kai-Sheng Hsieh Li-Tung Huang Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems Lipids in Health and Disease Prenatal glucocorticoid High-fat diet Adipose tissue Renin–angiotensin system |
author_facet |
Hong-Ren Yu You-Lin Tain Mao-Meng Tiao Chih-Cheng Chen Jiunn-Ming Sheen I-Chun Lin Shih-Wen Li Ching-Chou Tsai Yu-Ju Lin Kai-Sheng Hsieh Li-Tung Huang |
author_sort |
Hong-Ren Yu |
title |
Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems |
title_short |
Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems |
title_full |
Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems |
title_fullStr |
Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems |
title_full_unstemmed |
Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems |
title_sort |
prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin–angiotensin systems |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2018-03-01 |
description |
Abstract Background Hypertension may result from high-fat (HF) diet induced-obesity and overexposure to glucocorticoids in utero. Recent studies demonstrated the potent contribution of adipose tissue’s renin-angiotensin system (RAS) to systemic RAS, which plays a key role in regulating blood pressure (BP). In this study, we investigated the effects of prenatal dexamethasone (DEX) exposure and postnatal HF diet on RAS of adipose tissue. Methods RAS and BP of 6-month old rats exposed to prenatal DEX and/or postnatal HF diet were examined. Results Prenatal DEX plus postnatal HF exerted a synergistic effect on systolic BP. Prenatal DEX exposure suppressed plasma angiotensin (ANG) I and ANG II, whereas postnatal HF suppressed plasma ANG-(1–7) level. Prenatal DEX increased prorenin receptor and renin levels, but suppressed angiotensinogen (AGT) and angiotensin-converting-enzyme 1 (ACE1) mRNA expressions in adipose tissue. Postnatal HF increased AGT mRNA expression, but suppressed prorenin receptor, renin, ACE2, ANG II type 2 receptor (AT2R), and Mas receptor (MasR) mRNA expression levels. Conclusions Prenatal GC exposure altered the ACE1/ANG II/ANG II type 1 receptor (AT1R) axis, whereas postnatal HF negatively impacted the ACE2/ANG-(1–7)/MasR axis. Prenatal DEX exposure and postnatal HF synergistically elevated BP through a distinct programming mechanism of systemic and adipose RAS. Adipose RAS might be a target for precise hypertension treatment. |
topic |
Prenatal glucocorticoid High-fat diet Adipose tissue Renin–angiotensin system |
url |
http://link.springer.com/article/10.1186/s12944-018-0701-0 |
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