Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment

Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment

Extracellular vesicles (EVs) shed by cancer cells play a major role in mediating the transfer of molecular information by reprogramming the tumor microenvironment (TME). <i>TP53</i> (encoding the p53 protein) is the most mutated gene across many cancer types. Mutations in <i>TP53&l...

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Bibliographic Details
Main Authors: Bibek Bhatta, Ishai Luz, Christian Krueger, Fanny Xueting Teo, David P. Lane, Kanaga Sabapathy, Tomer Cooks
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
mutant p53 protein
extracellular vesicles
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/12/2985

Internet

https://www.mdpi.com/2072-6694/13/12/2985

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