Cell-mediated Immunity to AAV vectors, evolving concepts and potential solutions

Adeno-associated virus (AAV) vectors are one of the most efficient in vivo gene delivery platforms. Over the past decade, clinical trials of AAV vector-mediated gene transfer led to some of the most exciting results in the field of gene therapy and, recently, to the market approval of an AAV-based d...

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Bibliographic Details
Main Authors: Etiena eBasner-Tschakarjan, Federico eMingozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00350/full