Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (ASXL1) gene are common genetic abnormalities in human myeloid malignancies and induce clonal expansion of mutated hematopoietic stem cells (HSCs). To understand how ASXL1 disruption leads to myeloid cell...

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Bibliographic Details
Main Authors: Evisa Gjini, Chang-Bin Jing, Ashley T. Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J. Rodig, Marc R. Mansour, Keith Joung, A. Thomas Look
Format: Article
Language:English
Published: The Company of Biologists 2019-05-01
Series:Disease Models & Mechanisms
Subjects:
Apoptosis
Hematopoietic stem cells
Myeloproliferative neoplasms
Tet2
Genome editing
Online Access:http://dmm.biologists.org/content/12/5/dmm035790

Internet

http://dmm.biologists.org/content/12/5/dmm035790

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