α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Damage-associated molecular patterns (DAMPs) are molecules exposed or released by dead cells that trigger or modulate immunity and tissue repair. In vertebrates, the cytoskeletal component F-actin is a DAMP specifically recognised by DNGR-1, an innate immune receptor. Previously we suggested that ac...

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Bibliographic Details
Main Authors: Oliver Gordon, Conor M Henry, Naren Srinivasan, Susan Ahrens, Anna Franz, Safia Deddouche, Probir Chakravarty, David Phillips, Roger George, Svend Kjaer, David Frith, Ambrosius P Snijders, Rita S Valente, Carolina J Simoes da Silva, Luis Teixeira, Barry Thompson, Marc S Dionne, Will Wood, Caetano Reis e Sousa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
innate immunity
damage-associated molecular pattern
tissue injury
JAK/STAT pathway
DAMP
sterile inflammation
Online Access:https://elifesciences.org/articles/38636

Internet

https://elifesciences.org/articles/38636

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