CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway

CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway

Our previous study demonstrated that CopA3, a disulfide dimerof the coprisin peptide analogue (LLCIALRKK), has antibacterialactivity. In this study, we assessed whether CopA3caused cellular toxicity in various mammalian cell lines.CopA3 selectively caused a marked decrease in cell viabilityin Jurkat...

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Bibliographic Details
Main Authors: Bo Ram Kang, Ho Kim, Sung-Hee Nam, Eun-Young Yun, Seong-Ryul Kim, Mi-Young Ahn, Jong Soo Chang, Jae Sam Hwang
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2012-02-01
Series:BMB Reports
Subjects:
Anti-cancer effect
Apoptosis
Caspase-independent apoptosis pathways
Cell membrane penetration
Insect peptide
Leukemia
Online Access:http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0yJTVEMTIwMjI3MTA0NV8lMjgwODUtMDkwJTI5Qk1CMTEtMTI2LnBkZg==

Internet

http://bmbreports.org/jbmb/pdf.php?data=MTMxMTA4MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0yJTVEMTIwMjI3MTA0NV8lMjgwODUtMDkwJTI5Qk1CMTEtMTI2LnBkZg==

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