Bilirubin Induces Pain Desensitization in Cholestasis by Activating 5-Hydroxytryptamine 3A Receptor in Spinal Cord

Bilirubin Induces Pain Desensitization in Cholestasis by Activating 5-Hydroxytryptamine 3A Receptor in Spinal Cord

BackgroundCholestasis patients often suffer from pain desensitization, resulting in serious complications in perioperative period. This study was aim to investigate the mechanism of bilirubin in cholestasis mediating pain desensitization through 5-hydroxytryptamine 3A (5-HT3A) receptor activation in...

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Bibliographic Details
Main Authors: Erliang Kong, Hongqian Wang, Xiaoqiang Wang, Yan Zhang, Jinmin Zhang, Weifeng Yu, Xudong Feng, Yuming Sun, Feixiang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
bilirubin
cholestasis
5-HT3A receptor
pain desensitization
GABA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.605855/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.605855/full

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