Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer

<p>Abstract</p> <p>Background</p> <p>Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue extracts confounds scientif...

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Bibliographic Details
Main Authors: Platt Manu O, Chen Binbin
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/9/1/109