Complementarity of binding motifs is a general property of HLA-A and HLA-B molecules and does not seem to effect HLA haplotype composition

Complementarity of binding motifs is a general property of HLA-A and HLA-B molecules and does not seem to effect HLA haplotype composition

Different HLA haplotypes (i.e., the specific combinations of HLA-A, -B, -DR alleles inherited together from one parent) are observed in different frequencies in human populations. Some haplotypes, like HLA-A1-B8, are very frequent, reaching up to 10% in the Caucasian population, while others are ver...

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Bibliographic Details
Main Authors: Xiangyu eRao, Rob J De Boer, Debbie evan Baarle, Martin eMaiers, Can eKesmir
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Haplotypes
HLA Antigens
Selection, Genetic
Bioinformatics & Computational Biology
Peptide binding
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00374/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00374/full

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