SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production

SIRPα on Mouse B1 Cells Restricts Lymphoid Tissue Migration and Natural Antibody Production

The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an innate immune checkpoint and its targeting has shown promising results in cancer patients. Here, we report expression of SIRPα on B1 lymphocyt...

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Bibliographic Details
Main Authors: Katka Franke, Saravanan Y. Pillai, Mark Hoogenboezem, Marion J. J. Gijbels, Hanke L. Matlung, Judy Geissler, Hugo Olsman, Chantal Pottgens, Patrick J. van Gorp, Maria Ozsvar-Kozma, Yasuyuki Saito, Takashi Matozaki, Taco W. Kuijpers, Rudi W. Hendriks, Georg Kraal, Christoph J. Binder, Menno P. J. de Winther, Timo K. van den Berg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
B1 cells
natural antibodies
atherosclerosis
immune checkpoint
inhibitory receptor
SIRPα
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.570963/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.570963/full

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