Cysteine-based 3-substituted 1,5-benzoxathiepin derivatives: Two new classes of anti-proliferative agents

Cysteine-based 3-substituted 1,5-benzoxathiepin derivatives: Two new classes of anti-proliferative agents

Two distinct series of the 3-amino-1,5-benzoxathiepin scaffold, derived from L-cysteine, were synthesized and evaluated for their anti-proliferative activity in the breast cancer MDA-MB-231 and MCF-7 cells, and in the ovarian carcinoma SKOV-3 cell line. (3R)-Amino-3,4-dihydro-2H-1,5-benzoxathiepin [...

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Bibliographic Details
Main Authors: Nawal Mahfoudh, Nagore I. Marín-Ramos, Ana M. Gil, Ana I. Jiménez, Duane Choquesillo-Lazarte, Daniel F. Kawano, Joaquín M. Campos, Carlos Cativiela
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Arabian Journal of Chemistry
Subjects:
α-Amino acid
Benzoxathiepin
Density functional theory
Harpoon’s base
Purine
Tributyltin/iodination
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535217300308

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http://www.sciencedirect.com/science/article/pii/S1878535217300308

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