Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

We investigate the in vivo patterns of stem cell divisions in the human hematopoietic system throughout life. In particular, we analyze the shape of telomere length distributions underlying stem cell behavior within individuals. Our mathematical model shows that these distributions contain a fingerp...

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Bibliographic Details
Main Authors: Benjamin Werner, Fabian Beier, Sebastian Hummel, Stefan Balabanov, Lisa Lassay, Thorsten Orlikowsky, David Dingli, Tim H Brümmendorf, Arne Traulsen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
telomere length distribution
stem cell
mathematical modelling
hematopoiesis
self renewal
personalised medicine
Online Access:https://elifesciences.org/articles/08687

Internet

https://elifesciences.org/articles/08687

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