Interleukin-34 Limits the Therapeutic Effects of Immune Checkpoint Blockade

Interleukin-34 Limits the Therapeutic Effects of Immune Checkpoint Blockade

Summary: Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage. In this study, we show that tumor-derived IL-34 mediates resistance to immune checkpoint blockade regardless of CSF-1 ex...

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Bibliographic Details
Main Authors: Naoki Hama, Takuto Kobayashi, Nanumi Han, Fumihito Kitagawa, Nabeel Kajihara, Ryo Otsuka, Haruka Wada, Hee-kyung Lee, Hwanseok Rhee, Yoshinori Hasegawa, Hideo Yagita, Muhammad Baghdadi, Ken-ichiro Seino
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307768

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220307768

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