Role of N-terminal amino acids in the potency of anthrax lethal factor.

Role of N-terminal amino acids in the potency of anthrax lethal factor.

Anthrax lethal factor (LF) is a Zn(+2)-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF (LF-HMA) which differs from wild type LF (LF-A) by the addition of two residues (His-Met) to the nat...

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Bibliographic Details
Main Authors: Pradeep K Gupta, Mahtab Moayeri, Devorah Crown, Rasem J Fattah, Stephen H Leppla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2518864?pdf=render

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