Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression

Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression

Differentiation of oligodendrocyte progenitor cells (OPC) to oligodendrocytes and subsequent axon myelination are critical steps in vertebrate central nervous system (CNS) development and regeneration. Growing evidence supports the significance of mechanical factors in oligodendrocyte biology. Here,...

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Bibliographic Details
Main Authors: Krystyn J. Van Vliet, Anna Jagielska, Alexis L. Lowe, Ekta Makhija, Liliana Wroblewska, Jochen Guck, Robin J. M. Franklin, G. V. Shivashankar
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
oligodendrocytes
oligodendrocyte precursor cell (OPC)
oligodendrocyte differentiation
mechanical strain
multiple sclerosis (MS)
mechanotransduction
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00093/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00093/full

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