Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast

Summary: Expansions of simple DNA repeats cause numerous hereditary disorders in humans. Replication, repair, and transcription are implicated in the expansion process, but their relative contributions are yet to be distinguished. To separate the roles of replication and transcription in the expansi...

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Bibliographic Details
Main Authors: Kartik A. Shah, Ryan J. McGinty, Vera I. Egorova, Sergei M. Mirkin
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009176